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fragrance
Grade reflects published research findings and regulatory status. Not a safety certification.
Ingredient evidence is still under review.
Presence ≠ Risk. Educational summary only. Not medical advice.
A Parade of Persistent and Emerging Contact Allergens - A Clinical Update.
Current allergy and asthma reports · 2026
View on PubMed
RIFM fragrance ingredient safety assessment, p-tolualdehyde, CAS Registry Number 104-87-0.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
The existing information supports the use of this material as described in this safety assessment.
View on PubMed
Allergic Contact Dermatitis From Medical Adhesive Tape Used for Friction Blister Prevention in the Norwegian Armed Forces: A Case Series.
Contact dermatitis · 2026
View on PubMed
RIFM fragrance ingredient safety assessment, β-caryophyllene, CAS Registry Number 87-44-5.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
The existing information supports the use of this material as described in this safety assessment.
View on PubMed
15-Year Experience of Patch Testing During Pregnancy: Retrospective case-control study from a Tertiary Israeli Center.
Dermatology (Basel, Switzerland) · 2026
View on PubMed
RIFM fragrance ingredient safety assessment, hexadeca-1,5-lactone, CAS Registry Number 7370-44-7.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
The existing information supports the use of this material as described in this safety assessment.
View on PubMed
Fragrance allergic contact dermatitis.
Dermatitis : contact, atopic, occupational, drug · 2014
Fragrances are established as a common cause of allergic contact dermatitis, capable of eliciting reactions ranging from contact urticaria to systemic contact dermatitis.
View on PubMed
RIFM low-exposure fragrance ingredients safety assessment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
Safety assessments for a subset of 167 low-exposure fragrance ingredients indicated that current usage levels remain below thresholds for genotoxicity, systemic toxicity, and skin sensitization.
View on PubMed
Essential Oils as Natural Sources of Fragrance Compounds for Cosmetics and Cosmeceuticals.
Molecules (Basel, Switzerland) · 2021
The industry is increasingly shifting toward natural essential oils for fragrance due to concerns regarding potential adverse health risks associated with artificial fragrance chemicals.
View on PubMed
Grades are based on published peer-reviewed research, regulatory agency data (FDA, EU, IARC, WHO, EPA), and independent analysis. We update entries when new findings emerge.
fragrance
Moderate concern
Ingredient evidence is still under review.
FDA: no ruling
IARC: not evaluated
EU: approved
EPA: no reference dose found
California Prop 65: not listed
FDA: Allowed in cosmetics
EU_SCCS: Approved
Prop_65: Not listed
FDA: FDA fragrance page states fragrance ingredients in cosmetics must meet the same safety requirement as other cosmetic ingredients
labeled or customary cosmetic use · 2026-05-06
View sourceFDA/eCFR: 21 CFR 701.3 allows cosmetic fragrance or flavor to be listed as fragrance or flavor in the ingredient declaration
cosmetic ingredient declaration context · 2026-05-06
View sourceFDA: FDA MoCRA materials identify fragrance allergen labeling requirements as a new cosmetics regulatory area
fragrance-allergen labeling rulemaking context · 2026-05-06
View sourceA Parade of Persistent and Emerging Contact Allergens - A Clinical Update.
Current allergy and asthma reports · 2026
Read studyRIFM fragrance ingredient safety assessment, p-tolualdehyde, CAS Registry Number 104-87-0.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
The existing information supports the use of this material as described in this safety assessment.
Read studyAllergic Contact Dermatitis From Medical Adhesive Tape Used for Friction Blister Prevention in the Norwegian Armed Forces: A Case Series.
Contact dermatitis · 2026
Read studyRIFM fragrance ingredient safety assessment, β-caryophyllene, CAS Registry Number 87-44-5.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
The existing information supports the use of this material as described in this safety assessment.
Read study15-Year Experience of Patch Testing During Pregnancy: Retrospective case-control study from a Tertiary Israeli Center.
Dermatology (Basel, Switzerland) · 2026
Read studyRIFM fragrance ingredient safety assessment, hexadeca-1,5-lactone, CAS Registry Number 7370-44-7.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
The existing information supports the use of this material as described in this safety assessment.
Read studyFragrance allergic contact dermatitis.
Dermatitis : contact, atopic, occupational, drug · 2014
Fragrances are established as a common cause of allergic contact dermatitis, capable of eliciting reactions ranging from contact urticaria to systemic contact dermatitis.
Read studyRIFM low-exposure fragrance ingredients safety assessment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
Safety assessments for a subset of 167 low-exposure fragrance ingredients indicated that current usage levels remain below thresholds for genotoxicity, systemic toxicity, and skin sensitization.
Read studyEssential Oils as Natural Sources of Fragrance Compounds for Cosmetics and Cosmeceuticals.
Molecules (Basel, Switzerland) · 2021
The industry is increasingly shifting toward natural essential oils for fragrance due to concerns regarding potential adverse health risks associated with artificial fragrance chemicals.
Read study| California Prop 65 |
| not listed |
| — |
| — |
| View |
| FDA | Allowed in cosmetics | — | — | — |
| EU_SCCS | Approved | — | — | — |
| Prop_65 | Not listed | — | — | — |
| FDA | FDA fragrance page states fragrance ingredients in cosmetics must meet the same safety requirement as other cosmetic ingredients | labeled or customary cosmetic use | 2026-05-06 | View |
| FDA/eCFR | 21 CFR 701.3 allows cosmetic fragrance or flavor to be listed as fragrance or flavor in the ingredient declaration | cosmetic ingredient declaration context | 2026-05-06 | View |
| FDA | FDA MoCRA materials identify fragrance allergen labeling requirements as a new cosmetics regulatory area | fragrance-allergen labeling rulemaking context | 2026-05-06 | View |
